Snake venom disintegrins update: insights about new findings

Snake venom disintegrins are low molecular weight, non-enzymatic proteins rich in cysteine, present the of snakes from families Viperidae, Crotalidae, Atractaspididae, Elapidae, and Colubridae. This family originated through proteolytic processing metalloproteinases (SVMPs), which, turn, evolved a gene encoding an A Disintegrin And Metalloprotease (ADAM) molecule. Disintegrins have recognition motif for integrins their structure, allowing interaction with these transmembrane adhesion receptors preventing binding to extracellular matrix other cells. gives wide range biological functions, including inhibition platelet aggregation antitumor activity. As result, many studies been conducted attempt use natural compounds as basis developing therapies treatment various diseases. Furthermore, FDA has approved Tirofiban Eptifibatide antiplatelet compounds, they synthesized structure echistatin barbourin, respectively. In this review, we discuss some main functional structural characteristics class potential therapeutic use.